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Article

The development of genome-wide association studies and their application to complex diseases, including lupus.

Lupus - 1 Oct 2013

Bentham J, Vyse T J

Abstract excerpt

In this review, we explain the motivation for carrying out genome-wide association studies (GWAS), contrasting the achievements of linkage-based experiments for Mendelian traits with the difficulties found when applying that type of experiment to complex diseases. We explain the technical and organizational developments that were required to make GWAS feasible, as well as some of the theoretical concerns that...

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Identifiers

PMID: 24097992
DOI: 10.1177/0961203313492870

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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