Article
Finding genes for SLE: complex interactions and complex populations.
Journal of autoimmunity - 1 Sept 2003
Alarcón-Riquelme Marta E, Prokunina Ludmila
Abstract excerpt
Many years of work, multiplex family collection and endless genotyping finally give fruit. The original aim cannot be lost. The aim is not only to identify mutations involved in susceptibility for systemic lupus erythematosus (SLE) but to elucidate the disease pathogenesis as well. After genetics comes the biology. We review our recent findings on the genetics of lupus, provide possible mechanisms for disease...
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