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Article

The Post-GWAS Era: How to Validate the Contribution of Gene Variants in Lupus.

Current rheumatology reports - 23 Jan 2019

Fike Adam J, Elcheva Irina, Rahman Ziaur S M

Abstract excerpt

PURPOSE OF REVIEW: Systemic lupus erythematosus (SLE) is a complex autoimmune disease with strong genetic associations. Here, we provide an update on recent advancements in validating SLE candidate genes and risk variants identified in genome-wide association studies (GWAS). RECENT FINDINGS: A pairing of computational biology with new and emerging techniques has significantly increased our understanding of SLE...

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PMID: 30673885
DOI: 10.1007/s11926-019-0801-5

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