The PARK2 gene is involved in the maintenance of pancreatic β-cell functions related to insulin production and secretion.

doi:10.1016/j.mce.2013.09.031

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Article

The PARK2 gene is involved in the maintenance of pancreatic β-cell functions related to insulin production and secretion.

Molecular and cellular endocrinology - 25 Jan 2014

Jin Hyun-Seok, Kim Jeonghyun, Lee Soo-Jin, Kim Kyunga, Go Min Jin, Lee Jong-Young, Lee Hye-Ja, Song Jihyun, Jeon Byeong Tak, Roh Gu Seob, Kim Sung-Jun, Kim Bo-Young, Hong Kyung-Won, Yoo Young-Hyun, Oh Beomseok, Kang Yup, Jeong Seon-Yong

Abstract excerpt

Several association studies have implicated the PARK2 gene that encodes parkin--the key molecule orchestrating the mitochondrial quality control system--as a candidate susceptibility gene for diabetes. A total of 7551 unrelated Korean KARE cohort subjects were analyzed to investigate the association between the PARK2 single nucleotide polymorphism (SNP) and quantitative glycemic traits. Two SNPs, rs10455889 and...

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PMID: 24096089
DOI: 10.1016/j.mce.2013.09.031

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