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Article

In vitro expanded human CD4+CD25+ regulatory T cells are potent suppressors of T-cell-mediated xenogeneic responses.

Transplantation - 27 Jun 2008

Wu Jingjing, Yi Shounan, Ouyang Li, Jimenez Elvira, Simond Denbigh, Wang Wei, Wang Yiping, Hawthorne Wayne J, O'Connell Philip J

Abstract excerpt

BACKGROUND: Cellular rejection of xenografts is predominantly mediated by CD4 T cells. Little is known of the effectiveness of CD4CD25 T regulatory (Treg) cells at suppressing this strong T-cell mediated immune response. In this study, we evaluated the activity of fresh Treg cells and expanded Treg cells to suppress the xeno immune response in vitro. METHODS: Human Treg cells were preferentially expanded by...

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Source

Identifiers

PMID: 18580479
DOI: 10.1097/TP.0b013e3181734793

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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