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Article

Predictive biomarkers of sensitivity to the aurora and angiogenic kinase inhibitor ENMD-2076 in preclinical breast cancer models.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2013

Diamond Jennifer R, Eckhardt S Gail, Tan Aik Choon, Newton Timothy P, Selby Heather M, Brunkow Kelsey L, Kachaeva Maria I, Varella-Garcia Marileila, Pitts Todd M, Bray Mark R, Fletcher Graham C, Tentler John J

Abstract excerpt

PURPOSE: The Aurora kinases are a family of conserved serine-threonine kinases with key roles in mitotic cell division. As with other promising anticancer targets, patient selection strategies to identify a responsive subtype will likely be required for successful clinical development of Aurora kinase inhibitors. The purpose of this study was to evaluate the antitumor activity of the Aurora and angiogenic kinase...

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Identifiers

PMID: 23136197
DOI: 10.1158/1078-0432.CCR-12-1611
PMCID: PMC3537923

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