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Article

Prevalence of first-step mutants among levofloxacin-susceptible invasive isolates of Streptococcus pneumoniae in the United States.

Antimicrobial agents and chemotherapy - 1 Apr 2006

Pletz Mathias W R, Shergill Ardaman P, McGee Lesley, Beall Bernard, Whitney Cynthia G, Klugman Keith P

Abstract excerpt

By use of a PCR-restriction fragment length polymorphism assay, we screened 496 levofloxacin-susceptible invasive pneumococcal strains (MIC<or=2 mg/liter) for quinolone resistance-determining region mutations known to confer fluoroquinolone resistance. Among those with a levofloxacin MIC of 2 mg/liter, 16.2% of isolates recovered from nursing home residents and 6.4% from non-nursing home residents had first-step...

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Identifiers

PMID: 16569885
DOI: 10.1128/AAC.50.4.1561-1563.2006
PMCID: PMC1426940

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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