Article
Phenotyping dividing cells in mouse models of neurodegenerative basal ganglia diseases.
BMC neuroscience - 3 Oct 2013
Smardencas Arthur, Rizkalla Kerelos, Kim Hyun Ah, Massalas Jim, O'Leary Claire, Ehrlich Michelle E, Schütz Günter, Lawrence Andrew J, Drago John
Abstract excerpt
BACKGROUND: Mice generated by a Cre/LoxP transgenic paradigm were used to model neurodegenerative basal ganglia disease of which Huntington disease (HD) is the prototypical example. In HD, death occurs in striatal projection neurons as well as cortical neurons. Cortical and striatal neurons that express the D1 dopamine receptor (Drd1a) degenerate in HD. The contribution that death of specific neuronal cell...
Topics
- Animals
- Basal Ganglia Diseases
- Cell Count
- Cell Lineage
- Cell Proliferation
- Disease Models, Animal
- Huntington Disease
- Ki-67 Antigen
- Mice
- Mice, Transgenic
- Microglia
- Microscopy, Fluorescence
- Neurodegenerative Diseases