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Article

Phenotyping dividing cells in mouse models of neurodegenerative basal ganglia diseases.

BMC neuroscience - 3 Oct 2013

Smardencas Arthur, Rizkalla Kerelos, Kim Hyun Ah, Massalas Jim, O'Leary Claire, Ehrlich Michelle E, Schütz Günter, Lawrence Andrew J, Drago John

Abstract excerpt

BACKGROUND: Mice generated by a Cre/LoxP transgenic paradigm were used to model neurodegenerative basal ganglia disease of which Huntington disease (HD) is the prototypical example. In HD, death occurs in striatal projection neurons as well as cortical neurons. Cortical and striatal neurons that express the D1 dopamine receptor (Drd1a) degenerate in HD. The contribution that death of specific neuronal cell...

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Identifiers

PMID: 24090101
DOI: 10.1186/1471-2202-14-111
PMCID: PMC3851877

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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