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Article

An epistatic interaction between the PAX8 and STK17B genes in papillary thyroid cancer susceptibility.

PloS one - 1 Jan 2013

Landa Iñigo, Boullosa Cesar, Inglada-Pérez Lucía, Sastre-Perona Ana, Pastor Susana, Velázquez Antonia, Mancikova Veronika, Ruiz-Llorente Sergio, Schiavi Francesca, Marcos Ricard, Malats Nuria, Opocher Giuseppe, Diaz-Uriarte Ramon, Santisteban Pilar, Valencia Alfonso, Robledo Mercedes

Abstract excerpt

Papillary Thyroid Cancer (PTC) is a heterogeneous and complex disease; susceptibility to PTC is influenced by the joint effects of multiple common, low-penetrance genes, although relatively few have been identified to date. Here we applied a rigorous combined approach to assess both the individual and epistatic contributions of genetic factors to PTC susceptibility, based on one of the largest series of thyroid...

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Source

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Identifiers

PMID: 24086368
DOI: 10.1371/journal.pone.0074765
PMCID: PMC3781145

Genes

PAX8
TSHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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