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Reduced Mitochondrial DNA Content Associates with Poor Prognosis of Prostate Cancer in African American Men

23 Sept 2013

Abstract excerpt

Reduction or depletion of mitochondrial DNA (mtDNA) has been associated with cancer progression. Although imbalanced mtDNA content is known to occur in prostate cancer, differences in mtDNA content between African American (AA) and Caucasian American (CA) men are not defined. We provide the first evidence that tumors in AA men possess reduced level of mtDNA compared to CA men. The median tumor mtDNA content was...

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PMID: 24086362
DOI: 10.1371/journal.pone.0074688

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