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Article

CYP2B6, CYP2A6 and UGT2B7 genetic polymorphisms are predictors of efavirenz mid-dose concentration in HIV-infected patients.

AIDS (London, England) - 23 Oct 2009

Kwara Awewura, Lartey Margaret, Sagoe Kwamena W C, Kenu Ernest, Court Michael H

Abstract excerpt

OBJECTIVE: UDP-glucuronosyltransferase (UGT) 2B7 was recently identified as the main enzyme mediating efavirenz N-glucuronidation. In this study, we determined whether selected UGT2B7 polymorphisms could be used to enhance the prediction of efavirenz plasma concentrations from CYP2B6 and CYP2A6 genotypes. METHODS: Mid-dose efavirenz plasma concentrations were determined in 94 HIV-infected Ghanaian patients at 2-8...

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Source

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Identifiers

PMID: 19779319
DOI: 10.1097/QAD.0b013e3283319908
PMCID: PMC2875867

Variants

rs28365062

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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