Article
Gene polymorphisms of Interleukin-4 in allergic rhinitis and its association with clinical phenotypes.
American journal of otolaryngology - 1 Jan 2000
Movahedi Masoud, Amirzargar Ali Akbar, Nasiri Rasoul, Hirbod-Mobarakeh Armin, Farhadi Elham, Tavakol Marzieh, Behniafard Nasrin, Ansaripour Bita, Moradi Batoul, Zare Ahad, Rezaei Nima
Abstract excerpt
BACKGROUND: Allergic rhinitis (AR) is an inflammatory disorder of the upper airway. T-helper (Th)2 cytokines seems to have major roles behind the scene of unpleasant symptoms resulted from AR. Expression of interleukin (IL)-4 and its receptor could be affected by single nucleotide polymorphisms (SNPs). This study assessed the effect of 4 genetic variants within genes of IL-4 and IL-4R in AR. METHODS: Allele...
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