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Article

ALG-2 Attenuates COPII Budding In Vitro and Stabilizes the Sec23/Sec31A Complex

19 Sept 2013

Abstract excerpt

Coated vesicles mediate the traffic of secretory and membrane cargo proteins from the endoplasmic reticulum (ER) to the Golgi apparatus. The coat protein complex (COPII) involved in vesicle budding is constituted by a GTPase, Sar1, the inner coat components of Sec23/Sec24 and the components of the outer coat Sec13/Sec31A. The Ca(2+)-binding protein ALG-2 was recently identified as a Sec31A binding partner and a...

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PMID: 24069399
DOI: 10.1371/journal.pone.0075309

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ALG-2 Attenuates COPII Budding In Vitro and Stabilizes the Sec23/Sec31A ComplexPMID 24069399Read ↗

Mammalian ESCRT-III-related protein IST1 has a distinctive met-pro repeat sequence that is essential for interaction with ALG-2 in the presence of Ca2+.Semantic proximity Read ↗

ALG-2 oscillates in subcellular localization, unitemporally with calcium oscillations.Semantic proximity Read ↗

Sar1p N-terminal helix initiates membrane curvature and completes the fission of a COPII vesicle.Semantic proximity Read ↗

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The second C2-domain of copine-2, copine-6 and copine-7 is responsible for their calcium-dependent membrane association.Semantic proximity Read ↗

Mutational analysis of betaCOP (Sec26p) identifies an appendage domain critical for function.Semantic proximity Read ↗

Sar1 GTPase Activity Is Regulated by Membrane Curvature.Semantic proximity Read ↗

Smy2p participates in COPII vesicle formation through the interaction with Sec23p/Sec24p subcomplex.Semantic proximity Read ↗

A role for BARS at the fission step of COPI vesicle formation from Golgi membrane.Semantic proximity Read ↗

Novel binding sites on clathrin and adaptors regulate distinct aspects of coat assembly.Semantic proximity Read ↗

Yeast Cls2p/Csg2p localized on the endoplasmic reticulum membrane regulates a non-exchangeable intracellular Ca2+ pool cooperatively with calcineurin.Semantic proximity Read ↗

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