Article
Yeast Cls2p/Csg2p localized on the endoplasmic reticulum membrane regulates a non-exchangeable intracellular Ca2+ pool cooperatively with calcineurin.
FEBS letters - 22 Jan 1996
Tanida I, Takita Y, Hasegawa A, Ohya Y, Anraku Y
Abstract excerpt
Saccharromyces cerevisiae CLS2 gene product (Cls2p) that is localized on the endoplasmic reticulum is important for the regulation of intracellular Ca2+ in a compartment distinct from the vacuole. Using a vma3 mutation that impairs the Ca2+ sequestering activity into the vacuole, we have shown th...
Topics
- Calcineurin
- Calcium
- Calcium-Binding Proteins
- Calmodulin-Binding Proteins
- Cell Compartmentation
- Endoplasmic Reticulum
- Fungal Proteins
- Immunosuppressive Agents
- Intracellular Fluid
- Models, Biological
- Mutation
- Phosphoprotein Phosphatases
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Tacrolimus