[Activation of protooncogenes by point mutations in hematological malignancies].

Article

[Activation of protooncogenes by point mutations in hematological malignancies].

Nihon rinsho. Japanese journal of clinical medicine - 1 Jun 1992

Goto T, Nishimura J

Abstract excerpt

The activation of protooncogenes (ras, fms and myc genes) by point mutations in hematological malignancies are described in this review. Ras mutations are found in a variety of human malignancies at codon 12, 13, and 61. Generally, N-ras mutations are frequent in hematological malignancies. Fms m...

Topics

Animals
Gene Expression Regulation, Neoplastic
Genes, fms
Genes, myc
Genes, ras
Humans
Leukemia
Lymphoma
Mutation
Protein-Tyrosine Kinases
Proto-Oncogenes
Translocation, Genetic

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