Article
The consequence of oncomorphic TP53 mutations in ovarian cancer.
International journal of molecular sciences - 23 Sept 2013
Brachova Pavla, Thiel Kristina W, Leslie Kimberly K
Abstract excerpt
Ovarian cancer is the most lethal gynecological malignancy, with an alarmingly poor prognosis attributed to late detection and chemoresistance. Initially, most tumors respond to chemotherapy but eventually relapse due to the development of drug resistance. Currently, there are no biological markers that can be used to predict patient response to chemotherapy. However, it is clear that mutations in the tumor...
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