Article
Contribution of superoxide dismutase and catalase activities to Shigella flexneri pathogenesis.
Infection and immunity - 1 Feb 1990
Franzon V L, Arondel J, Sansonetti P J
Abstract excerpt
A Shigella flexneri serotype 5 strain deficient in the production of the iron-containing superoxide dismutase FeSOD (sodB) and a catalase-negative (katFG) S. flexneri serotype 5 strain were isolated. Both strains were examined for increased sensitivity to oxygen stress by using assays involving killing by mouse peritoneal macrophages and human polymorphonuclear leukocytes as well as infection of rabbit ileal...
Topics
- Animals
- Catalase
- Keratoconjunctivitis
- Mice
- Mice, Inbred BALB C
- Mutation
- Oxidation-Reduction
- Phagocytosis
- Rabbits
- Shigella flexneri
- Superoxide Dismutase
- Virulence