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Article

Biochemical Analysis of the Plasmodium falciparum Erythrocyte-binding Antigen-175 (EBA175)-Glycophorin-A Interaction

16 Sept 2013

Abstract excerpt

Pf EBA175 has an important role in the invasion of human erythrocytes by Plasmodium falciparum and is therefore considered a high priority blood-stage malaria vaccine candidate. Pf EBA175 mediates adhesion to erythrocytes through binding of the Duffy-binding-like (DBL) domains in its extracellular domain to Neu5Acα2–3Gal displayed on the O -linked glycans of glycophorin-A (GYPA). Because of the difficulties in...

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PMID: 24043627
DOI: 10.1074/jbc.m113.484840

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