Article
Targeted disruption of an erythrocyte binding antigen in Plasmodium falciparum is associated with a switch toward a sialic acid-independent pathway of invasion.
Proceedings of the National Academy of Sciences of the United States of America - 20 Jun 2000
Reed M B, Caruana S R, Batchelor A H, Thompson J K, Crabb B S, Cowman A F
Abstract excerpt
Erythrocyte invasion by Plasmodium requires molecules present both on the merozoite surface and within the specialized organelles of the apical complex. The Plasmodium erythrocyte binding protein family includes the Plasmodium falciparum sialic acid-binding protein, EBA-175 (erythrocyte binding antigen-175), which binds sialic acid present on glycophorin A of human erythrocytes. We address the role of the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.