Article
Tools for characterizing bacterial protein synthesis inhibitors.
Antimicrobial agents and chemotherapy - 1 Dec 2013
Orelle Cédric, Carlson Skylar, Kaushal Bindiya, Almutairi Mashal M, Liu Haipeng, Ochabowicz Anna, Quan Selwyn, Pham Van Cuong, Squires Catherine L, Murphy Brian T, Mankin Alexander S
Abstract excerpt
Many antibiotics inhibit the growth of sensitive bacteria by interfering with ribosome function. However, discovery of new protein synthesis inhibitors is curbed by the lack of facile techniques capable of readily identifying antibiotic target sites and modes of action. Furthermore, the frequent rediscovery of known antibiotic scaffolds, especially in natural product extracts, is time-consuming and expensive and...
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