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Article

EZH2 is a negative prognostic biomarker associated with immunosuppression in hepatocellular carcinoma

12 Nov 2020

Abstract excerpt

The enhancer of zeste homolog 2 (EZH2) plays a critical role in different components of anti-tumor immunity. However, the specific role of EZH2 in modulating MHC Class I antigen presentation and T cell infiltration have not been investigated in HCC. This study analyzed the expression and clinical significance of EZH2 in HCC. The EZH2 genetic alterations were identified using cBioPortal. The EZH2 mRNA and protein...

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PMID: 33180829
DOI: 10.1371/journal.pone.0242191

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