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Article

Distinct ubiquitin binding modes exhibited by SH3 domains: molecular determinants and functional implications.

PloS one - 1 Jan 2013

Ortega Roldan Jose L, Casares Salvador, Ringkjøbing Jensen Malene, Cárdenes Nayra, Bravo Jerónimo, Blackledge Martin, Azuaga Ana I, van Nuland Nico A J

Abstract excerpt

SH3 domains constitute a new type of ubiquitin-binding domains. We previously showed that the third SH3 domain (SH3-C) of CD2AP binds ubiquitin in an alternative orientation. We have determined the structure of the complex between first CD2AP SH3 domain and ubiquitin and performed a structural an...

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Source

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Identifiers

PMID: 24039852
DOI: 10.1371/journal.pone.0073018
PMCID: PMC3770644

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-24039852-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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