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Article

Polymorphism of the complement receptor 1 gene correlates with the hematologic response to eculizumab in patients with paroxysmal nocturnal hemoglobinuria.

Haematologica - 1 Feb 2014

Rondelli Tommaso, Risitano Antonio M, Peffault de Latour Régis, Sica Michela, Peruzzi Benedetta, Ricci Patrizia, Barcellini Wilma, Iori Anna Paola, Boschetti Carla, Valle Veronica, Frémeaux-Bacchi Veronique, De Angioletti Maria, Socie Gerard, Luzzatto Lucio, Notaro Rosario

Abstract excerpt

Complement blockade by eculizumab is clinically effective in hemolytic paroxysmal nocturnal hemoglobinuria. However, the response is variable and some patients remain dependent on red blood cell transfusions. In 72 patients with hemolytic paroxysmal nocturnal hemoglobinuria on eculizumab we tested the hypothesis that response may depend on genetic polymorphisms of complement-related genes. We found no correlation...

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Share to Antibodies, Monoclonal, Humanized
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24038027
DOI: 10.3324/haematol.2013.090001
PMCID: PMC3912955

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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