Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondrial translation factors of Trypanosoma brucei: elongation factor-Tu has a unique subdomain that is essential for its function.

Molecular microbiology - 1 Nov 2013

Cristodero Marina, Mani Jan, Oeljeklaus Silke, Aeberhard Lukas, Hashimi Hassan, Ramrath David J F, Lukeš Julius, Warscheid Bettina, Schneider André

Abstract excerpt

Mitochondrial translation in the parasitic protozoan Trypanosoma brucei relies on imported eukaryotic-type tRNAs as well as on bacterial-type ribosomes that have the shortest known rRNAs. Here we have identified the mitochondrial translation elongation factors EF-Tu, EF-Ts, EF-G1 and release factor RF1 of trypanosomatids and show that their ablation impairs growth and oxidative phosphorylation. In vivo labelling...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Electron Transport Complex IV
Share to Oxidative Phosphorylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Peptide Elongation Factor G

Share to Peptide Elongation Factor Tu

Share to Peptide Elongation Factors

Share to Peptide Termination Factors

Share to Ribosomes

Share to Trypanosoma brucei brucei

Source

Identifiers

PMID: 24033548
DOI: 10.1111/mmi.12397

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial translation factors of Trypanosoma brucei: elongation factor-Tu has a unique subdomain that is essential for its function.PMID 24033548Read ↗

Bacterial elongation factors EF-Tu, their mutants, chimeric forms, and domains: isolation and purification.Semantic proximity Read ↗

Structural differences in translation initiation between pathogenic trypanosomatids and their mammalian hostsSemantic proximity Read ↗

Mitochondrial translation: elongation factor tu is essential in fission yeast and depends on an exchange factor conserved in humans but not in budding yeast.Semantic proximity Read ↗

Structural Differences in Translation Initiation between Pathogenic Trypanosomatids and Their Mammalian HostsSemantic proximity Read ↗

Structure of the mature kinetoplastids mitoribosome and insights into its large subunit biogenesisSemantic proximity Read ↗

Identification and Validation of Toxoplasma gondii Mitoribosomal Large Subunit ComponentsSemantic proximity Read ↗

Distinct mRNA and protein interactomes highlight functional differentiation of major eIF4F-like complexes from Trypanosoma bruceiSemantic proximity Read ↗

Functional characterization of two paralogs that are novel RNA binding proteins influencing mitochondrial transcripts of Trypanosoma bruceiSemantic proximity Read ↗

A very rare presentation of mitochondrial elongation factor Tu deficiency-TUFM mutation and literature review.Semantic proximity Read ↗

Extensive Translational Regulation through the Proliferative Transition of Trypanosoma cruzi Revealed by Multi-OmicsSemantic proximity Read ↗

Trypanosoma brucei Homologue of Regulator of Ribosome Synthesis 1 (Rrs1) Has Direct Interactions with Essential Trypanosome-Specific ProteinsSemantic proximity Read ↗

A tRNA half modulates translation as stress response in Trypanosoma bruceiSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.