Article
Piliation of invasive Streptococcus pneumoniae isolates in the era before pneumococcal conjugate vaccine introduction in Malawi.
Clinical and vaccine immunology : CVI - 1 Nov 2013
Kulohoma Benard W, Gray Katherine, Kamng'ona Arox, Cornick Jennifer, Bentley Stephen D, Heyderman Robert S, Everett Dean B
Abstract excerpt
The pneumococcal pilus has been shown to be an important determinant of adhesion and virulence in mouse models of colonization, pneumonia, and bacteremia. A pilus is capable of inducing protective immunity, supporting its inclusion in next-generation pneumococcal protein vaccine formulations. Whe...
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