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CREB1 activation promotes human papillomavirus oncogene expression and cervical cancer cell transformation

1 Aug 2023

Abstract excerpt

Human papillomaviruses (HPVs) infect the oral and anogenital mucosa and can cause cancer. The high-risk (HR)-HPV oncoproteins, E6 and E7, hijack cellular factors to promote cell proliferation, delay differentiation and induce genomic instability, thus predisposing infected cells to malignant transformation. cAMP response element (CRE)-binding protein 1 (CREB1) is a master transcription factor that can function as...

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PMID: 37565725
DOI: 10.1002/jmv.29025

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