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Article

Dyrk1A-mediated phosphorylation of RCAN1 promotes the formation of insoluble RCAN1 aggregates.

Neuroscience letters - 25 Oct 2013

Song Woo-Joo, Song Eun-Ah Christine, Choi Sun-Hee, Baik Hyung-Hwan, Jin Byung Kwan, Kim Jeong Hee, Chung Sul-Hee

Abstract excerpt

The mechanisms underlying aggregate formation in age-related neurodegenerative diseases remain not well understood. Here we investigated whether dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A (Dyrk1A) is involved in the formation of regulator of calcineurin 1 (RCAN1) aggregates. We show that RCAN1 self-associates and forms multimers, and that this process is promoted by the Dyrk1A-mediated...

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Source

Identifiers

PMID: 24021800
DOI: 10.1016/j.neulet.2013.08.066

Genes

RCAN1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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