Article
Effect of mutations in lipooligosaccharide biosynthesis genes on virulence of Haemophilus influenzae type b.
Infection and immunity - 1 Jul 1990
Cope L D, Yogev R, Mertsola J, Argyle J C, McCracken G H, Hansen E J
Abstract excerpt
Chemical mutagenesis techniques and genetic transformation methods were used to construct isogenic mutants of Haemophilus influenzae type b (Hib) defective in the ability to synthesize lipooligosaccharide (LOS). A mutant (17B) which expressed a LOS molecule with an altered oligosaccharide was less virulent than the wild-type parent strain, as determined by measurement of the ability of these strains to produce...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.