Article
Effect of mutations in lipooligosaccharide biosynthesis genes on virulence of Haemophilus influenzae type b.
Infection and immunity - 1 Jul 1990
Cope L D, Yogev R, Mertsola J, Argyle J C, McCracken G H, Hansen E J
Abstract excerpt
Chemical mutagenesis techniques and genetic transformation methods were used to construct isogenic mutants of Haemophilus influenzae type b (Hib) defective in the ability to synthesize lipooligosaccharide (LOS). A mutant (17B) which expressed a LOS molecule with an altered oligosaccharide was les...
Topics
- Administration, Intranasal
- Animals
- Antibodies, Monoclonal
- Antigens, Bacterial
- Antigens, Surface
- Bacterial Capsules
- Bacterial Outer Membrane Proteins
- Bacterial Vaccines
- Cell Division
- Epitopes
- Haemophilus Infections
- Haemophilus Vaccines
- Haemophilus influenzae
- Lipopolysaccharides