Article
Identification of a lipopolysaccharide alpha-2,3-sialyltransferase from Haemophilus influenzae.
Molecular microbiology - 1 Jan 2001
Hood D W, Cox A D, Gilbert M, Makepeace K, Walsh S, Deadman M E, Cody A, Martin A, Månsson M, Schweda E K, Brisson J R, Richards J C, Moxon E R, Wakarchuk W W
Abstract excerpt
We have identified a gene for the addition of N-acetylneuraminic acid (Neu5Ac) in an alpha-2,3-linkage to a lactosyl acceptor moiety of the lipopolysaccharide (LPS) of the human pathogen Haemophilus influenzae. The gene is one that was identified previously as a phase-variable gene known as lic3A. Extracts of H. influenzae, as well as recombinant Escherichia coli strains producing Lic3A, demonstrate...
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