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Article

Poor metabolizers at the cytochrome P450 2C19 loci is at increased risk of developing cancer in Asian populations.

PloS one - 1 Jan 2013

Wang Hong, Song Kang, Chen Zenggan, Yu Yanmin

Abstract excerpt

BACKGROUND: CYP2C19 encodes a member of the cytochrome P450 superfamily of enzymes, which play a central role in activating and detoxifying many carcinogens and endogenous compounds thought to be involved in the development of cancer. In the past decade, two common polymorphisms among CYP2C19 (CYP2C19*2 and CYP2C19*3) that are responsible for the poor metabolizers (PMs) phenotype in humans and cancer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24015291
DOI: 10.1371/journal.pone.0073126
PMCID: PMC3754911

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