Article
Systematic pharmacogenomics analysis of a Malay whole genome: proof of concept for personalized medicine.
PloS one - 1 Jan 2013
Salleh Mohd Zaki, Teh Lay Kek, Lee Lian Shien, Ismet Rose Iszati, Patowary Ashok, Joshi Kandarp, Pasha Ayesha, Ahmed Azni Zain, Janor Roziah Mohd, Hamzah Ahmad Sazali, Adam Aishah, Yusoff Khalid, Hoh Boon Peng, Hatta Fazleen Haslinda Mohd, Ismail Mohamad Izwan, Scaria Vinod, Sivasubbu Sridhar
Abstract excerpt
BACKGROUND: With a higher throughput and lower cost in sequencing, second generation sequencing technology has immense potential for translation into clinical practice and in the realization of pharmacogenomics based patient care. The systematic analysis of whole genome sequences to assess patient to patient variability in pharmacokinetics and pharmacodynamics responses towards drugs would be the next step in...
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