Recent developments in the understanding of the combined deficiency of FV and FVIII.

doi:10.1111/j.1365-2141.2008.07559.x

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Article

Recent developments in the understanding of the combined deficiency of FV and FVIII.

British journal of haematology - 1 Apr 2009

Zhang Bin

Abstract excerpt

Combined deficiency of factor V (FV) and factor VIII (FVIII) (F5F8D) is a genetic disorder characterized by mild-to-moderate bleeding and coordinate reduction in plasma FV and FVIII levels, as well as platelet FV level. Recent studies identified mutations in two genes (LMAN1 and MCFD2) as the cause of F5F8D. Though clinically indistinguishable, MCFD2 mutations generally exhibit lower levels of FV and FVIII than...

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Identifiers

PMID: 19183188
DOI: 10.1111/j.1365-2141.2008.07559.x
PMCID: PMC2777536

Genes

LMAN1
MCFD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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