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Fast development of Pichia pastoris GS115 Mut(+) cultures employing batch-to-batch control and hybrid semi-parametric modeling.

Bioprocess and biosystems engineering - 1 Apr 2014

Ferreira A R, Dias J M L, von Stosch M, Clemente J, Cunha A E, Oliveira Rui

Abstract excerpt

In this paper, we implemented a model-based optimization platform for fast development of Pichia pastoris cultures employing batch-to-batch control and hybrid semi-parametric modeling. We illustrate the methodology with a P. pastoris GS115 strain expressing a single-chain antibody fragment (scFv) by determining the optimal time profiles of temperature, pH, glycerol feeding and methanol feeding that maximize the...

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PMID: 24009018
DOI: 10.1007/s00449-013-1029-9

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Source receipt: pubmed, retrieved 7 Sept 2026.

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