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Article

Clonal leukemic evolution in myelodysplastic syndromes with TET2 and IDH1/2 mutations.

Haematologica - 1 Jan 2014

Lin Tung-Liang, Nagata Yasunobu, Kao Hsiao-Wen, Sanada Masashi, Okuno Yusuke, Huang Chein-Fuang, Liang Der-Cherng, Kuo Ming-Chung, Lai Chang-Liang, Lee En-Hui, Shih Yu-Shu, Tanaka Hiroko, Shiraishi Yuichi, Chiba Kenichi, Lin Tung-Huei, Wu Jin-Hou, Miyano Satoru, Ogawa Seishi, Shih Lee-Yung

Abstract excerpt

Somatic mutations of TET2, IDH1, and IDH2 have been described in myelodysplastic syndrome. The impact of these mutations on outcome of myelodysplastic syndrome and their progression to secondary acute myeloid leukemia remains unclear. Mutation status of TET2, IDH1 and IDH2 was investigated in a c...

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Identifiers

PMID: 23996483
DOI: 10.3324/haematol.2013.091249
PMCID: PMC4007920

Genes

TET2
IDH1
IDH2
FLT3
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23996483-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Clonal leukemic evolution in myelodysplastic syndromes with TET2 and IDH1/2 mutations.PMID 23996483Read ↗

Epigenetic dysregulation in myelodysplastic syndromes.Semantic proximity Read ↗

TET2 mutations in myelodysplasia and myeloid malignancies.Semantic proximity Read ↗

Mutation in TET2 in myeloid cancers.Semantic proximity Read ↗

TET2 mutational status affects myelodysplastic syndrome evolution to chronic myelomonocytic leukemiaSemantic proximity Read ↗

Acquired mutations in TET2 are common in myelodysplastic syndromes.Semantic proximity Read ↗

[Molecular and clinical characteristics and prognosis of myelodysplastic neoplasms with biallelic TET2 inactivation].Semantic proximity Read ↗

Significance of JAK2 and TET2 mutations in myelodysplastic syndromes.Semantic proximity Read ↗

IDH1 and IDH2 mutations in myelodysplastic syndromes and role in disease progressionSemantic proximity Read ↗

[Research progress on genes associated with transformation of myelodysplastic syndromes to acute myeloid leukemia].Semantic proximity Read ↗

IDH1 mutations in patients with myelodysplastic syndromes are associated with an unfavorable prognosis.Semantic proximity Read ↗

Mutations of IDH1 and IDH2 genes in early and accelerated phases of myelodysplastic syndromes and MDS/myeloproliferative neoplasmsSemantic proximity Read ↗

Detection of Dual IDH1 and IDH2 Mutations by Targeted Next-Generation Sequencing in Acute Myeloid Leukemia and Myelodysplastic Syndromes.Semantic proximity Read ↗

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