Article
The proteasome-associated protein Ecm29 inhibits proteasomal ATPase activity and in vivo protein degradation by the proteasome.
The Journal of biological chemistry - 11 Oct 2013
De La Mota-Peynado Alina, Lee Stella Yu-Chien, Pierce Brianne Marie, Wani Prashant, Singh Chingakham Ranjit, Roelofs Jeroen
Abstract excerpt
Several proteasome-associated proteins regulate degradation by the 26 S proteasome using the ubiquitin chains that mark most substrates for degradation. The proteasome-associated protein Ecm29, however, has no ubiquitin-binding or modifying activity, and its direct effect on substrate degradation is unclear. Here, we show that Ecm29 acts as a proteasome inhibitor. Besides inhibiting the proteolytic cleavage of...
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