Article
Deubiquitination by proteasome is coordinated with substrate translocation for proteolysis in vivo.
Experimental cell research - 15 Jul 2005
Zhu Qianzheng, Wani Gulzar, Wang Qi-en, El-mahdy Mohamed, Snapka Robert M, Wani Altaf A
Abstract excerpt
The 26S proteasome mediates degradation of protein substrates labeled with polyUb chains. After recognition by the 19S proteasome regulatory complex, polyUb chains are disassembled and substrates are processed in the 20S core of proteasome. However, the exact relationship of degradation-associated deubiquitination to substrate processing remains unclear. Here, using Ub-based tagging strategies, we provided...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.