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Article

Elastin Haploinsufficiency Impedes the Progression of Arterial Calcification in MGP-Deficient Mice

15 Jul 2013

Abstract excerpt

Matrix gla protein (MGP) is a potent inhibitor of extracellular matrix (ECM) mineralization. MGP-deficiency in humans leads to Keutel syndrome, a rare genetic disease hallmarked by abnormal soft tissue calcification. MGP-deficient (Mgp(-/-)) mice show progressive deposition of hydroxyapatite minerals in the arterial walls and die within 2 months of age. The mechanism of antimineralization function of MGP is not...

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PMID: 23857752
DOI: 10.1002/jbmr.2039

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