A human cytomegalovirus early promoter with upstream negative and positive cis-acting elements: IE2 negates the effect of the negative element, and NF-Y binds to the positive element.

doi:10.1128/JVI.68.4.2108-2117.1994

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Article

A human cytomegalovirus early promoter with upstream negative and positive cis-acting elements: IE2 negates the effect of the negative element, and NF-Y binds to the positive element.

Journal of virology - 1 Apr 1994

Huang L, Malone C L, Stinski M F

Abstract excerpt

The human cytomegalovirus early promoter for the UL4 gene, which codes for an early viral envelope glycoprotein designated gpUL4, requires immediate-early viral protein two (IE2) synthesis to be activated (C.-P. Chang, C. L. Malone, and M. F. Stinski, J. Virol. 63:281, 1989). We investigated the...

Topics

Acid Phosphatase
Base Sequence
CCAAT-Enhancer-Binding Proteins
Cytomegalovirus
DNA Mutational Analysis
DNA-Binding Proteins
Fibroblasts
Gene Expression Regulation, Viral
Humans
Immediate-Early Proteins
Membrane Glycoproteins
Molecular Sequence Data
Mutation
Promoter Regions, Genetic

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Identifiers

PMID: 8138995
DOI: 10.1128/JVI.68.4.2108-2117.1994
PMCID: PMC236685

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8138995-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Protein Binding

Trans-Activators

Transcription Factors

Viral Envelope Proteins