Article
Oxidative DNA damage, antioxidants, and cancer.
BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Mar 1999
Collins A R
Abstract excerpt
Oxidised bases, such as 8-oxo-guanine, occur in cellular DNA as a result of attack by oxygen free radicals. The cancer-protective effect of vegetables and fruit is attributed to the ability of antioxidants in them to scavenge free radicals, preventing DNA damage and subsequent mutation. Antioxidant supplements (e.g., beta-carotene, vitamin C) increase the resistance of lymphocytes to oxidative damage, and a...
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