Article
NOD2 gene variants are a risk factor for culture-positive spontaneous bacterial peritonitis and monomicrobial bacterascites in cirrhosis.
Liver international : official journal of the International Association for the Study of the Liver - 1 Feb 2012
Bruns Tony, Peter Jack, Reuken Philipp A, Grabe Dominik H, Schuldes Sonja R, Brenmoehl Julia, Schölmerich Jürgen, Wiest Reiner, Stallmach Andreas
Abstract excerpt
BACKGROUND: Spontaneous bacterial peritonitis (SBP) is considered as result of bacterial translocation from the gastrointestinal lumen to the mesenteric lymph nodes and subsequent circulation. Variants of the NOD2 gene contribute to bacterial translocation and were associated with SBP in a recent study. METHODS: We determined common NOD2 variants by TaqMan polymerase chain reaction and analysed the ascitic fluid...
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