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Article

Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice.

Diabetes - 1 Jun 2008

Cani Patrice D, Bibiloni Rodrigo, Knauf Claude, Waget Aurélie, Neyrinck Audrey M, Delzenne Nathalie M, Burcelin Rémy

Abstract excerpt

OBJECTIVE: Diabetes and obesity are characterized by a low-grade inflammation whose molecular origin is unknown. We previously determined, first, that metabolic endotoxemia controls the inflammatory tone, body weight gain, and diabetes, and second, that high-fat feeding modulates gut microbiota and the plasma concentration of lipopolysaccharide (LPS), i.e., metabolic endotoxemia. Therefore, it remained to...

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PMID: 18305141
DOI: 10.2337/db07-1403

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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