Article
Production of ELOVL4 transgenic pigs: a large animal model for Stargardt-like macular degeneration.
The British journal of ophthalmology - 1 Dec 2011
Sommer Jeffrey R, Estrada Jose L, Collins Edwin B, Bedell Matthew, Alexander Curtis A, Yang Zhenglin, Hughes Guy, Mir Bashir, Gilger Brian C, Grob Seanna, Wei Xinran, Piedrahita Jorge A, Shaw Peter X, Petters Robert M, Zhang Kang
Abstract excerpt
BACKGROUND: Truncation mutations in the elongation of very long chain fatty acids-4 (AF277094, MIM #605512) (ELOVL4) gene cause Stargardt-like macular dystrophy type 3 (STGD3). Mice expressing truncated ELOVL4 develop rapid retinal degeneration, but are poor STGD3 models since mice lack a macula. Photoreceptor topography in the pig retina is more similar to that in humans as it includes the cone rich, macula-like...
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