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Article

Human PIEZO1: removing inactivation.

Biophysical journal - 20 Aug 2013

Bae Chilman, Gottlieb Philip A, Sachs Frederick

Abstract excerpt

PIEZO1 is an inactivating eukaryotic cation-selective mechanosensitive ion channel. Two sites have been located in the channel that when individually mutated lead to xerocytotic anemia by slowing inactivation. By introducing mutations at two sites, one associated with xerocytosis and the other ar...

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Source

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Identifiers

PMID: 23972840
DOI: 10.1016/j.bpj.2013.07.019
PMCID: PMC3752115

Genes

PIEZO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23972840-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Human PIEZO1: removing inactivation.PMID 23972840Read ↗

Human PIEZO1 Ion Channel Functions as a Split Protein.Semantic proximity Read ↗

The Kinetics and the Permeation Properties of Piezo Channels.Semantic proximity Read ↗

Voltage-gating of mechanosensitive PIEZO channelsSemantic proximity Read ↗

Mechanisms of PIEZO Channel Inactivation.Semantic proximity Read ↗

Piezo1: properties of a cation selective mechanical channel.Semantic proximity Read ↗

Mechanisms of PIEZO Channel InactivationSemantic proximity Read ↗

Structure, kinetic properties and biological function of mechanosensitive Piezo channelsSemantic proximity Read ↗

Piezo-Type Mechanosensitive Ion Channel Component 1 (Piezo1): A Promising Therapeutic Target and Its Modulators.Semantic proximity Read ↗

Structural Analysis of Piezo1 Ion Channel Reveals the Relationship between Amino Acid Sequence Mutations and Human DiseasesSemantic proximity Read ↗

Identification and functional characterization of the Piezo1 channel pore domain.Semantic proximity Read ↗

Small-molecule functional rescue of PIEZO1 channel variants associated with generalised lymphatic dysplasiaSemantic proximity Read ↗

Mechanosensing by Piezo1 and its implications for physiology and various pathologiesSemantic proximity Read ↗

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