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Article

Dph3, a small protein required for diphthamide biosynthesis, is essential in mouse development.

Molecular and cellular biology - 1 May 2006

Liu Shihui, Wiggins Jason F, Sreenath Taduru, Kulkarni Ashok B, Ward Jerrold M, Leppla Stephen H

Abstract excerpt

The translation elongation factor 2 in eukaryotes (eEF-2) contains a unique posttranslationally modified histidine residue, termed diphthamide, which serves as the only target for diphtheria toxin and Pseudomonas aeruginosa exotoxin A. Diphthamide biosynthesis is carried out by five highly conser...

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Identifiers

PMID: 16648478
DOI: 10.1128/MCB.26.10.3835-3841.2006
PMCID: PMC1488998

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16648478-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Dph3, a small protein required for diphthamide biosynthesis, is essential in mouse development.PMID 16648478Read ↗

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The amidation step of diphthamide biosynthesis in yeast requires DPH6, a gene identified through mining the DPH1-DPH5 interaction network.Semantic proximity Read ↗

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