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Article

Q222R polymorphism in DNAse I gene is a risk factor for nephritis in South Indian SLE patients.

Lupus - 1 Sept 2013

Panneer D, Antony P T, Negi V S

Abstract excerpt

OBJECTIVE: Systemic lupus erythematosus (SLE) is a multisystem disorder in which defective apoptotic clearance is considered to be an important factor in pathogenesis. DNAse I is associated with disposal of apoptotic nuclear debris. The defective enzyme production due to +2373 A to G (Q222R) in exon 8 is reported to be a genetic risk factor for SLE. SLE in Indians is reported to be severe. There are no genetic...

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PMID: 23963431
DOI: 10.1177/0961203313498801

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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