Article
Mutations of keratin 9 in two families with palmoplantar epidermolytic hyperkeratosis.
The Journal of investigative dermatology - 1 Oct 1994
Bonifas J M, Matsumura K, Chen M A, Berth-Jones J, Hutchison P E, Zloczower M, Fritsch P O, Epstein E H
Abstract excerpt
The hereditary palmoplantar keratodermas are a heterogeneous group of diseases unified by thickening of the stratum corneum of the palms and soles with consequent painful fissuring, discomfort on pressure, and resultant disability. One of the histologic patterns underlying palmoplantar hyperkeratosis is that of epidermolytic hyperkeratosis. Because that histologic pattern has been found in its generalized form to...
Topics
- Base Sequence
- Family Health
- Female
- Humans
- Hyperkeratosis, Epidermolytic
- Keratins
- Keratoderma, Palmoplantar
- Male
- Molecular Sequence Data
- Mutation
- Pedigree