Article
Mutations in the keratin 9 gene in Pakistani families with epidermolytic palmoplantar keratoderma.
Clinical and experimental dermatology - 1 Oct 2010
Shimomura Y, Wajid M, Weiser J, Kraemer L, Christiano A M
Abstract excerpt
BACKGROUND: Keratins are heteropolymeric proteins that form the intermediate filament cytoskeleton in epithelial cells. The common basic structure of all keratins is organized in a central α-helical rod domain flanked by nonhelical, variable head and tail regions. Most mutations in keratins are found in the central α-helical rod domain. Keratin 9 (K9) is expressed only in the suprabasal layers of palmoplantar...
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