A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy.

doi:10.1093/hmg/ddt403

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Article

A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy.

Human molecular genetics - 1 Jan 2014

Speed Doug, Hoggart Clive, Petrovski Slave, Tachmazidou Ioanna, Coffey Alison, Jorgensen Andrea, Eleftherohorinou Hariklia, De Iorio Maria, Todaro Marian, De Tisham, Smith David, Smith Philip E, Jackson Margaret, Cooper Paul, Kellett Mark, Howell Stephen, Newton Mark, Yerra Raju, Tan Meng, French Chris, Reuber Markus, Sills Graeme E, Chadwick David, Pirmohamed Munir, Bentley David, Scheffer Ingrid, Berkovic Samuel, Balding David, Palotie Aarno, Marson Anthony, O'Brien Terence J, Johnson Michael R

Abstract excerpt

We present the analysis of a prospective multicentre study to investigate genetic effects on the prognosis of newly treated epilepsy. Patients with a new clinical diagnosis of epilepsy requiring medication were recruited and followed up prospectively. The clinical outcome was defined as freedom from seizures for a minimum of 12 months in accordance with the consensus statement from the International League...

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PMID: 23962720
DOI: 10.1093/hmg/ddt403
PMCID: PMC3857947

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