Article
Genotyping for polymorphic drug metabolizing enzymes from paraffin-embedded and immunohistochemically stained tumor samples.
Pharmacogenetics - 1 Aug 2003
Rae James M, Cordero Kevin E, Scheys Joshua O, Lippman Marc E, Flockhart David A, Johnson Michael D
Abstract excerpt
OBJECTIVES: Paraffin-embedded tumor samples are valuable in the study of cancer for routine staging, tumor marker analysis, and in retrospective studies to test new prognostic and predictive biomarkers. Their utility in retrospective pharmacogenetic analysis of clinical trials has yet to be evaluated. We set out to establish genotyping methods for relevant genes from archival tumor samples and determine if...
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