Article
Parp-1 deficiency in ES cells promotes invasive and metastatic lesions accompanying induction of trophoblast giant cells during tumorigenesis in uterine environment.
Pathology international - 1 Aug 2013
Nozaki Tadashige, Fujimori Hiroaki, Wang Junhui, Suzuki Hiroshi, Imai Hiroshi, Watanabe Masatoshi, Ohura Kiyoshi, Masutani Mitsuko
Abstract excerpt
Embryonic stem (ES) cells deficient in poly(ADP-ribose) polymerase-1 (Parp-1) develop into teratocarcinomas with the appearance of trophoblast giant cells (TGCs) when injected subcutaneously into nude mice. Because the uterus is one of the original organs in which germ cell tumors develop with in...
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